Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 43, Issue -, Pages 46-54Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.11.023
Keywords
-
Categories
Funding
- Technology Foundation of the Dutch National Science Foundation (NWO-TTW)
- Netherlands Organization for Scientific Research (NWO) [863.15.002]
- Netherlands Institute of Ecology, NIOO-KNAW [6427]
Ask authors/readers for more resources
Microbiomes contribute directly or indirectly to host health and fitness. Thus far, investigations into these emergent traits, referred to here as microbiome-associated phenotypes (MAPs), have been primarily qualitative and taxonomy-driven rather than quantitative and trait-based. We present the MAPs-first approach, a theoretical and experimental roadmap that involves quantitative profiling of MAPs across genetically variable hosts and subsequent identification of the underlying mechanisms. We outline strategies for developing 'modular microbiomes' synthetic microbial consortia that are engineered in concert with the host genotype to confer different but mutually compatible MAPs to a single host or host population. By integrating host and microbial traits, these strategies will facilitate targeted engineering of microbiomes to the benefit of agriculture, human/animal health and biotechnology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available