Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 32, Pages 17573-17581Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b05038
Keywords
anticancer-phospholipid complex; self-assembly; nanoparticles; targeted drug delivery; sustained/controlled drug release
Funding
- National Natural Science Foundation of China [31271071]
- Fujian Province Medical Innovation Project [2014-CXB-350]
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Integrating advantages of mitomycin C (MMC)-phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC- phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in He La tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.
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