Journal
FORENSIC SCIENCE INTERNATIONAL-GENETICS
Volume 16, Issue -, Pages E7-E10Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.fsigen.2014.11.018
Keywords
Y-STR; PPY23; Tibetan; DYS448
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Funding
- Five-twelfth National Science and Technology Support Program of China [2012BAK16B01]
- National Natural Science Foundation of China [81273349, 81330073]
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Tibetan is one of 56 ethnic groups in China, where a level of genetic sub-structure might be expected. Although a global analysis of Y-chromosomal haplotype diversity for 23 STR loci and Y-STR databases with PPY23 kit were created with collaborative effort, there was a lack of data for Tibetan population. In this study we evaluated 248 unrelated male individuals of Chinese Tibetan living in the Tibet Autonomous Region to explore the underlying genetic structure of Tibetan populations. These samples were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) by using PPY23 kit. A total of 224 different haplotypes were found. Haplotype diversity was 0.9990. Both R-st pairwise analyses and multidimensional scaling plot showed the genetic structure of Tibetan population was significantly different from some of Chinese ethnic groups and neighboring populations. There were few interesting null features at DYS448 observed by PPY23 that deserved some comment. It revealed that PPY23 marker set provided substantially stronger discriminatory power in Tibetan population. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
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