Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 48, Issue -, Pages 104-111Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2017.11.003
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Funding
- Department of Health and Human Services acting through the Victorian Cancer Agency [MCRF16007]
- Cancer Australia grant [CA 1084546]
- Australian National Health and Medical Research Council [361646]
- Victorian State Government Operational Infrastructure Support Grant
- Canadian Institutes of Health Research [PJT-148603]
- National Institutes of Health [CA202021-01-A1]
- Terry Fox New Frontiers Program in Cancer [TFRI 242115]
- NATIONAL CANCER INSTITUTE [R01CA202021] Funding Source: NIH RePORTER
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Translation is a pivotal step in the regulation of gene expression as well as one of the most energy consuming processes in the cell. Dysregulation of translation caused by the aberrant function of upstream signaling pathways and/or perturbations in the expression or function of components of the translation machinery is frequent in cancer. In this review, we discuss emerging findings that highlight hitherto unappreciated aspects of signaling to the translation apparatus with the particular focus on emerging connections between protein synthesis, autophagy and energy homeostasis in cancer.
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