Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 52, Issue -, Pages 22-28Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2018.04.008
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Funding
- Ministry of Innovation Science and Research of North Rhine-Westphalia
- ERA-NET NEURON, JTC 2015 Neurodevelopmental Disorders, STEM-MCD
- German Federal Ministry of Education and Research (BMBF) [01GQ1423B]
- Hector Foundation II
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The development of organoids derived from human pluripotent stem cells heralded a new area in studying human organ development and pathology outside of the human body. Triggered by the seminal work of pioneers in the field such as Yoshiki Sasai or Hans Clevers, organoid research has become one of the most rapidly developing fields in cell biology. The potential applications are manifold reaching from developmental studies to tissue regeneration and drug screening. In this review, we will concentrate on brain organoids of cortical identity. We will describe the 'state of the art' in generating cortical organoids and discuss potential applications. Finally, we will provide future perspectives including suggestions how further innovations can broaden the application of brain organoids.
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