Journal
CURRENT OPINION IN CRITICAL CARE
Volume 24, Issue 5, Pages 370-378Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCC.0000000000000523
Keywords
aspiration; hospital-acquired infections; hospital-acquired pneumonia; oral care; prevention
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Funding
- Barnes-Jewish Hospital Foundation
- NIH [5T32 HL007317]
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Purpose of reviewHospital-acquired pneumonia (HAP) is the leading cause of death from hospital-acquired infection. Little work has been done on strategies for prevention of HAP. This review aims to describe potential HAP prevention strategies and the evidence supporting them. Oral care and aspiration precautions may attenuate some risk for HAP. Oral and digestive decontamination with antibiotics may be effective but could increase risk for resistant organisms. Other preventive measures, including isolation practices, remain theoretical or experimental.Recent findingsHospital-acquired pneumonia occurs because of pharyngeal colonization with pathogenic organisms and subsequent aspiration of these pathogens.SummaryMost potential HAP prevention strategies remain unproven.
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