Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 42, Issue -, Pages 111-118Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.11.009
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Funding
- National Institute of Environmental Health Sciences of the NIH [R01 ES022190]
- DOE [DE-AC05-76RL0 1830]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES022190, P42ES027704] Funding Source: NIH RePORTER
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Lipids are a vital class of molecules that play important and varied roles in biological processes, however, fully understanding these roles is extremely difficult due to the immense number and diversity of possible lipid species. While recent advances in chromatography and high resolution mass spectrometry have greatly progressed knowledge about distinct lipid species and functions, effectively separating many lipids still remains problematic. Isomeric lipids have made lipid characterization especially difficult and occur due to subclasses having the same chemical composition, or species having multiple acyl chain connectivities (sn-1, sn-2, or sn-3), double bond positions and orientations (cis or trans), and functional group stereochemistries (R versus S). To aid in isomer characterization, ion mobility spectrometry separations, ion-molecule reactions and fragmentation techniques have increasingly been added to lipid analysis workflows. In this manuscript, we review the current state of these approaches and their capabilities for improving the identification of lipid species.
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