Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 46, Issue -, Pages 71-81Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2018.05.022
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Funding
- EU Horizon 2020 program under the Marie Sklodowska-Curie [700124]
- Marie Curie Actions (MSCA) [700124] Funding Source: Marie Curie Actions (MSCA)
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Dehydroalanine has emerged in recent years as a non-proteinogenic residue with strong chemical utility in proteins for the study of biology. In this review we cover the several methods now available for its flexible and site-selective incorporation via a variety of complementary chemical and biological techniques and examine its reactivity, allowing both creation of modified protein side-chains through a variety of bond-forming methods (C-S, C-N, C-Se, C-C) and as an activity-based probe in its own right. We illustrate its utility with selected examples of biological and technological discovery and application.
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