Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 43, Issue -, Pages 97-105Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.12.003
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Funding
- Austrian BMWFW
- BMVIT
- SFG
- Standortagentur Tirol
- Government of Lower Austria
- Business Agency Vienna through the Austrian FFG-COMET-Funding Program
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The biocatalytic reduction of activated C=C-bonds is dominated by ene-reductases from the Old Yellow Enzyme family, which gained broad practical use owing to exquisite stereoselectivity combined with wide substrate scope. Protein diversity is fostered by mining distinct protein classes and by implementing protein engineering techniques. Recent efforts are focusing on expanding the chemical complexity of the product portfolio, either through substrate functionalization or design of multi-step reactions. This review also highlights unusual chemistries catalyzed by ene-reductases and presents emerging methodologies developed to bypass the need of natural nicotinamide cofactors.
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