Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 44, Issue -, Pages 93-100Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2018.05.007
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Funding
- Bill and Melinda Gates Foundation [OPP1126594]
- Bill and Melinda Gates Foundation [OPP1126594] Funding Source: Bill and Melinda Gates Foundation
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Mass spectrometry imaging (MSI) is a powerful label-free technique for visualizing drug and metabolite distributions in biological tissues. In this review, we discuss recent developments in MSI and spatial profiling technologies to visualize and quantify drug distributions in tissues. We also present recent examples of applications of these technologies for assessing drug distribution within tissues and individual cells. Finally, we focus on an emerging technique coupling laser capture microdissection (LCM) to quantitative mass spectrometry, which combines the respective advantages of imaging and conventional liquid chromatography mass spectrometry, and thus enables spatially resolved drug quantification.
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