Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 55, Issue -, Pages 8-16Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2018.06.006
Keywords
-
Categories
Funding
- DFG [SFB 655]
- ERC [250197]
Ask authors/readers for more resources
Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting with a technical comparison between pre-patterning and self-patterning brain organoid protocols. We then follow neocortex development in space and time and list those aspects where organoids have succeeded in emulating in vivo development, as well as those aspects that continue to be pending tasks. Finally, we present a summary of medical and evolutionary insight made possible by organoid technology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available