Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 52, Issue -, Pages 30-42Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2018.01.006
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Funding
- Cancer Prevention Research Institute of Texas (CPRIT) [RP150053, RP170170]
- National Institutes of Health (NIH) [R01-GM069909]
- Welch Foundation Grant [I-1532]
- University of Texas Southwestern Endowed Scholars Program
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Malfunction of nuclear-cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells. In addition to their nuclear transport functions in interphase, Karyopherin nuclear transport receptors also have important roles in mitosis and chromosomal integrity. Therefore, alterations in the expressions or regular functions of Karyopherins may have substantial effects on the course and outcome of diseases.
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