Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 50, Issue -, Pages 57-63Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2018.01.009
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Funding
- CNRS
- Inserm
- Universite Paris Descartes
- Fondation pour la Recherche Medicale ('Equipe FRM') [DEQ20130326518]
- ANRS (France Recherche Nord & Sud SIDA HIV Hepatites)
- Agence Nationale de la Recherche [ANR-2011-BSV3-025-02, ANR-16-CE13-0007-01]
- Canadian Institutes of Health Research [FDN-143202]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE13-0007] Funding Source: Agence Nationale de la Recherche (ANR)
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Phagocytosis is a complex and elegant mechanism requiring finely coordinated deformation and restructuring of the membrane and the underlying cytoskeleton. Here we discuss the early events of receptor clustering and engagement required for signal transduction and actin remodeling. In addition, we summarize recent studies of the mechanisms whereby the nascent phagosome seals and evolves into a degradative phagolysosome by a process that seemingly involves the autophagic machinery. These studies provided new insights of the molecular basis of this long-appreciated, essential homeostatic process.
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