Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 49, Issue -, Pages 16-22Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2017.07.003
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Funding
- National Science Foundation [MCB-1411949]
- National Institutes of Health [R01-GM107084]
- Direct For Biological Sciences [1411949] Funding Source: National Science Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM107084] Funding Source: NIH RePORTER
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The love affair between crop breeding and genetics began over a century ago and has continued unabated, from mass selection programs to targeted genome modifications. Synthetic genetic circuits, a recent development, are combinations of regulatory and coding DNA introduced into a crop plant to achieve a desired function. Genetic circuits could accelerate crop improvement, allowing complex traits to be rationally designed and requisite DNA parts delivered directly into a genome of interest. However, there is not yet a standardized pipeline from exploratory laboratory testing to crop trials, and bringing transgenic products to market remains a considerable barrier. We highlight successes so far and future developments necessary to make genetic circuits a viable crop improvement technology over this century.
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