4.7 Review

Synthetic genetic circuits in crop plants

Journal

CURRENT OPINION IN BIOTECHNOLOGY
Volume 49, Issue -, Pages 16-22

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2017.07.003

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Funding

  1. National Science Foundation [MCB-1411949]
  2. National Institutes of Health [R01-GM107084]
  3. Direct For Biological Sciences [1411949] Funding Source: National Science Foundation
  4. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM107084] Funding Source: NIH RePORTER

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The love affair between crop breeding and genetics began over a century ago and has continued unabated, from mass selection programs to targeted genome modifications. Synthetic genetic circuits, a recent development, are combinations of regulatory and coding DNA introduced into a crop plant to achieve a desired function. Genetic circuits could accelerate crop improvement, allowing complex traits to be rationally designed and requisite DNA parts delivered directly into a genome of interest. However, there is not yet a standardized pipeline from exploratory laboratory testing to crop trials, and bringing transgenic products to market remains a considerable barrier. We highlight successes so far and future developments necessary to make genetic circuits a viable crop improvement technology over this century.

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