Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 49, Issue -, Pages 156-162Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2017.08.012
Keywords
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Funding
- Swiss National Foundation [31003A-159998]
- Herbette Foundation
- European Research Council under the European Union's Seventh Framework Programme (FP)/ERC [310856]
- European Molecular Biology Organisation (EMBO) Young Investigator Programme
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Proteins containing a SPX domain are involved in phosphate (Pi) homeostasis, including Pi transport and adaptation to Pi deficiency. The SPX domain harbors a basic surface binding Pi at low affinity and inositol pyrophosphates (PP-InsPs) at high affinity. Genetic and biochemical studies revealed that PP-InsPs serve as ligands for the SPX domain. Residues in the PHO1 SPX domain involved in PP-InsPs binding are critical for its Pi export activity, and the interaction between SPX proteins and the PHR1 transcription factor, which results in PHRI inactivation, is promoted by PP-InsPs. Changes in PP-InsPs levels in response to Pi deficiency may thus contribute to the adaptation of plants to stress via the modulation of the activity of SPX-containing proteins and their interactors. Modulating PP-InsP levels or the affinity/specificity of the SPX domain for PP-InsP could potentially be used to engineer crops to maintain high yield under reduced Pi fertilizer input.
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