Journal
CURRENT MICROBIOLOGY
Volume 75, Issue 9, Pages 1190-1197Publisher
SPRINGER
DOI: 10.1007/s00284-018-1508-y
Keywords
-
Categories
Funding
- Natural Science Foundation of China [31371746]
- higher educational cultivation program for major scientific research projects of Guangdong Ocean University [GDOU2013050205, 2014050203]
- scientific research program of administration of quality and technology supervision of Guangdong province [2015ZZ02]
Ask authors/readers for more resources
Vibrio parahaemolyticus is a seafood opportunistic pathogen. There are evidences suggesting that virulence skills, including hemolytic activity and biofilm formation, are regulated by the luxM/luxS-dependent quorum-sensing system in V. parahaemolyticus, and their regulatory mechanism is not well understood. To better understand the virulence regulatory mechanism of V. parahaemolyticus, the luxM deletion (Delta luxM) and luxS deletion (Delta luxS) mutants were constructed and their impacts on growth, hemolysin activity, and biofilm were investigated. Results show that both luxM and luxS are involved in the adaptation to environmental conditions in early adaptive-log phase growth of V. parahaemolyticus. Thermostable direct hemolysin gene (tdh) was negatively regulated by luxM and positively regulated by luxS. The biofilm formation was negatively regulated by both luxS and luxM. This study provides an insight into some aspects of V. parahaemolyticus virulence regulation by luxM/luxS-dependent quorum-sensing system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available