Journal
CURRENT MEDICINAL CHEMISTRY
Volume 25, Issue 7, Pages 814-838Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867324666170918125155
Keywords
Flavonoids; autophagy; cancer; neurodegenerative disorders; cardiovascular diseases; hepatic diseases; infectious diseases; diabetes
Funding
- JCyL [LE063U16]
- Fondo Europeo de Desarrollo Regional (FEDER) [LE063U16]
- Spanish Ministry of Education, Culture and Sports [FPU13/04173]
- Instituto de la Salud Carlos III (Spain)
- CIBERehd contracts
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Background: Autophagy is a cellular pathway with the ability to maintain cell homeostasis through the elimination of damaged or useless cellular components, and its deregulation may initiate or aggravate different human diseases. Flavonoids, a group of plant metabolites, are able to modulate different molecular and cellular processes including autophagy. Objective: To review the effects of flavonoids on autophagy pathway in both invasive and non-invasive human diseases, focusing on the global outcomes in their progression. Moreover, the efficacy of the combination of flavonoids with drugs or other natural nontoxic compounds was also reviewed. Methods: A literature search was performed to identify and analyze peer-reviewed publications containing in vitro and in vivo studies focused on autophagy deregulation in different proliferative and non-proliferative pathologies and the potential protective effects of flavonoids. Results: Analyzed publications indicated that imbalance between cell death and survival induced by changes in autophagy play an important role in the pathophysiology of a number of human diseases. The use of different flavonoids as autophagy modulators, alone or in combination with other molecules, might be a worthy strategy in the treatment of cancer, neurodegenerative disorders, cardiovascular diseases, hepatic diseases, leishmaniasis, influenza, gastric ulcers produced by Helicobacter pylori infection, diabetes, asthma, age-related macular degeneration or osteoporosis. Conclusion: Flavonoids could potentially constitute important adjuvant agents of conventional therapies in the treatment of autophagy deregulation-related diseases. Moreover, combined therapy may help to diminish the doses of those conventional treatments, leading to reduced drug-derivative side effects and to improved patients' survival.
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