Journal
CURRENT MEDICINAL CHEMISTRY
Volume 25, Issue 19, Pages 2260-2271Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867325666180117101114
Keywords
CD73; ecto-5 '-nucleotidase; cancer; immunity; inflammation; disease
Funding
- Natural Science Foundation of China [81172507, 30971163]
Ask authors/readers for more resources
CD73, also known as ecto-5'-nucleotidase (eN, NT5E, EC3.13.5), is the rate limiting enzyme for adenosine generation and is expressed on multiple cells. Its expression is significantly influenced by hypoxia and inflammatory factors. During inflammation, CD73 protects endothelial barrier function and inhibits leukocyte trafficking. CD73 also promotes M2 macrophages (anti-inflammatory phenotype). In addition, CD73 is expressed on Treg cells and mediates immune suppression through adenosine. CD73 serves as an essential regulator for the immunity and inflammation. Its expression is related to many diseases, such as autoimmune diseases, ischemia-reperfusion injuries, arterial calcifications, and atherosclerosis. CD73 is overexpressed in many cancers. Its expression is positively associated with tumor growth, metastasis, angiogenesis, poor prognosis and resistance to chemotherapy. Thus, CD73 may be used for prognostic indicator and therapeutic target in diseases such as cancers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available