Journal
CURRENT GENETICS
Volume 64, Issue 5, Pages 971-983Publisher
SPRINGER
DOI: 10.1007/s00294-018-0819-7
Keywords
Genome stability; DNA damage response; DNA repair; RNA processing; R-loops
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Funding
- People Programme (Marie Curie Actions) European Union's Seventh Framework Programme (REA Grant) [609427]
- People Programme (Marie Curie Actions) European Union's Seventh Framework Programme (SASPRO Project) [0032/01/02]
- Slovak Academy of Sciences
- VEGA [2/0026/18, 2/0014/14, 2/0056/14]
- Slovak Research and Development Agency [APVV-16-120, APVV-0111-12, APVV-14-0783]
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Endogenous and exogenous factors can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. The protection of genome integrity is ensured by the so-called DNA damage response (DDR), a set of evolutionary-conserved events that, triggered upon DNA damage detection, arrests the cell cycle, and attempts DNA repair. Here, we review the role of the DDR proteins as post-transcriptional regulators of gene expression, in addition to their roles in DNA damage recognition, signaling, and repair. At the same time, we discuss recent insights into how pre-mRNA splicing factors go beyond their splicing activities and play direct functions in detecting, signaling, and repairing DNA damage. The importance of extensive two-way crosstalk and interaction between the RNA processing and the DDR stems from growing evidence that the defects of their communication lead to genomic instability.
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