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Antitumor Activity of Polysaccharides: An Overview

Journal

CURRENT DRUG TARGETS
Volume 19, Issue 1, Pages 89-96

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389450118666170704143018

Keywords

Polysaccharides; antitumor; biological activities; mechanisms; discuss; summarize

Funding

  1. Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
  2. Chongqing Key Research Project of Basic Science & Frontier Technology [cstc2017jcyjBX0012]
  3. Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJ1400523]
  4. Foundation Project of Chongqing Normal University [14XYY020]
  5. Chongqing General Research Project of Basic Science & Frontier Technology [cstc2015jcyjA10054]
  6. Chongqing Normal University Postgraduate's Research and Innovation Project [YKC17004]
  7. Open Foundation Project of University Engineering Research Center for Bioactive Substances in Chongqing [AS201614]
  8. Chongqing University Students' Training Project of Innovation & Undertaking, China [201610637076]

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Background: Polysaccharides are widely found in animals, plants and micro-organisms, and are closely related to various physiological functions. It is one of the four basic substances that constitute life activities. Polysaccharide has antitumor, antivirus, antioxidant, immune regulation and other biological activities. Objective: Because the polysaccharide has significant antitumor effect and small side-effects, it has become the focus of the current antitumor drug research. Results: Herein, the polysaccharide species with antitumor effect were summarized in recent years, and the antitumor activity mechanisms of polysaccharides were analyzed and discussed. Conclusion: Many polysaccharides have good antitumor activity, and they have broad application prospects.

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