Journal
CURRENT ALZHEIMER RESEARCH
Volume 15, Issue 3, Pages 283-300Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567205014666170417111859
Keywords
Tau; aggregation; phosphorylation; NFTs; Alzheimer's disease; therapy
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Funding
- National Natural Science Foundation of China [81471309, 81371406, 81571245, 81501103]
- Shandong Provincial Outstanding Medical Academic Professional Program
- Qingdao Key Health Discipline Development Fund
- Qingdao Outstanding Health Professional Development Fund
- Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders
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Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a microtubule-associated protein and a principle neuropathological hallmark of AD, provides us a neoteric perspective to explore further aetiopathogenesis and therapeutic strategy. The hyperphosphorylation and abnormal aggregation of tau, combined with its decreased clearance, form neurofibrillary tangles (NFTs) and exert neurotoxicity in AD. Methods: Recent investigations aim to prevent the deposition of NFT and accelerate the clearance of NFT. Intriguingly, immunization strategies targeting tau effectively ameliorates the tau-associated pathology in AD. In addition, modified therapies targeting tau should be regarded as a potential way to treat AD. These progresses open new avenues for AD. Conclusion: Here, we review the recent literature of potential mechanisms of the tau in AD and discuss the modified therapeutic strategies for AD.
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