Journal
CRYSTAL GROWTH & DESIGN
Volume 18, Issue 7, Pages 3740-3746Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.cgd.8b00683
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A new anhydrous polymorph of the free base of sildenafil and two solvates (acetonitrile and propanenitrile) have been discovered and fully characterized. The new polymorph can be considered a desolvate of the acetonitrile solvate and is related to the most stable form I by morphotropism. The new polymorph can only be obtained by desolvation of the acetonitrile solvate. Thus, this study is a new example of the importance of this multicomponent family of solid forms in the discovery of new polymorphs of active pharmaceutical ingredients.
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