Journal
CRYSTAL GROWTH & DESIGN
Volume 18, Issue 4, Pages 2067-2081Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.cgd.7b01523
Keywords
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Funding
- Fundacao para a Ciencia e a Tecnologia [PEst-OE/QUI/UI0100/2013, RECI/QEQ-QIN/0189/2012, SFRH/BPD/78854/2011]
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Nalidixic acid is an antibiotic from the quinolones family whose bioavailability is limited due to its low solubility. The development of complexes and bioinspired metal-organic frameworks has been explored as a way to achieve controlled drug delivery and release, and we demonstrate that they can also be used to tune drugs' physicochemical properties, such as solubility. Herein we disdose a series of complexes and frameworks of nalidixic acid and Zn. One of these frameworks duplicates the solubility of nalidixic acid, and it is stable on the shelf and to 77% room humidity. The incorporation of a second ligand into the frameworks is also presented, showing the possibility to develop extended networks with further potential applications.
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