Journal
RSC ADVANCES
Volume 5, Issue 97, Pages 79519-79524Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra15373e
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Funding
- National Natural Science Foundation of China [21342012, 21375037, 21507028]
- Hunan Provincial Natural Science Foundation of China [11JJ3023, 15JJ3094]
- Science and Technology Department [13JJ2020]
- State Key Laboratory of Chemo/Biosensing and Chemometrics Foundation [KLCBTC MR 2011-05]
- Scientific Research Fund of Hunan Provincial Education Department [13C635]
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A simple and reversible fluorescent probe bearing 7-nitrobenz-2-oxa-1,3-diazole and a selenomorpholine fragment was designed and synthesized. The probe showed highly selective, sensitive and fast (<10 s) recognition to hypochlorite in aqueous solutions. The relative results demonstrated that the linear response range of the probe was between 5.0 x 10(-8) M and 1.2 x 10(-4) M, with a low detection limit of 3.3 nM (S/N = 3). The probe was capable of monitoring hypochlorite reversibly in the presence of glutathione. In addition, the biological applications in living cells have been described.
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