Thermosalient Forms: Carryover of Thermosalient Behavior of Coformers from Single Component to Multicomponent Forms?

The solids salinazide (Slz) and 3-chloro-2-nitrobenzoic acid (CNB) are thermosalient (TS) in nature in their single component forms; upon cocrystallization with pentafluorobenzoic acid (PNB) and 4,4'-bipyridine (BPY), respectively, they produced a salt (Slz-PFB) and a cocrystal, CNB-BPY, which are also TS in nature. A detailed structural analysis of all the forms in question is carried out to verify if a solid that shows TS behavior in its single component form can be used as a TS template to generate new TS multicomponent solid forms. The study is significant as the multicomponent approach may allow the generation of a library of new TS forms, for instance, to alter the response time, temperature, etc. This may also allow imparting an additional functionality (e.g., mechanochromic luminescence, conductivity, chemical reactivity, etc.) to the new solids upon appropriate selection of coformer(s).