Journal
BIOMOLECULES
Volume 5, Issue 3, Pages 1938-1954Publisher
MDPI
DOI: 10.3390/biom5031938
Keywords
inflammation; cytokine; virus; macrophage; diabetes; Ccr5
Categories
Funding
- NIH [DK-052194, AI-44458]
- F30 Fellowship [DK102363-01A1]
- NIGMS [T32-GM080202]
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The expression and production of type 1 interferon is the classic cellular response to virus infection. In addition to this antiviral response, virus infection also stimulates the production of proinflammatory mediators. In this review, the pathways controlling the induction of inflammatory genes and the roles that these inflammatory mediators contribute to host defense against viral pathogens will be discussed. Specific focus will be on the role of the chemokine receptor CCR5, as a signaling receptor controlling the activation of pathways leading to virus-induced inflammatory gene expression.
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