Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 128, Issue -, Pages 43-57Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2018.05.014
Keywords
Glutathione; Oxidative stress; Preclinical models; Solid tumors; Cancer therapeutic
Categories
Funding
- CAPES [40001016038PO]
- CNPq [307977/2015-3]
Ask authors/readers for more resources
Glutathione (GSH) is one of the most important defenses against oxidative stress through the fine-tuned regulation of redox homeostasis. Glutathione is also involved in many metabolic processes and is important for the regulation of cell survival, proliferation, and death. Furthermore, GSH and the enzymes that are involved in its biosynthesis, catabolism, and detoxification (e.g., disulfide-oxidized glutathione, glutathione S-transferase, glutathione peroxidase, glutathione reductase, and gamma-glutamyltranspetidase) play an important role in several diseases, including cancer. In cancer cells, these enzymes protect the tumor microenvironment against oxidative stress and cell death and are important for tumor growth and development. Thus, the GSH system is an important tool for investigating new pharmacological approaches for cancer treatment. Several preclinical models of solid tumors are available for this purpose. This review summarizes and discusses the regulation and dysregulation of GSH and its related enzymes in different models of solid tumors, and potential treatments that target the GSH system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available