Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 123, Issue -, Pages 42-51Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2018.01.003
Keywords
Radiation; Lymphopenia; Systematic review; Chemotherapy
Categories
Funding
- MD Anderson Cancer Center [P30 CA16672]
- John E. and Dorothy J. Harris Endowed Professorship
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Lymphopenia is a common accompaniment of multimodal cancer therapy. As the most radiosensitive cells of the hematopoietic system, lymphocytes residing within or circulating through a radiation portal are frequently depleted by radiation therapy. The recognition that radiation-induced reduction of circulating lymphocyte counts and eventual lymphocyte infiltration of tumors have a tangible impact on overall survival outcomes has revived the interest in understanding the causes of treatment-associated lymphopenia and developing strategies to predict, prevent and ameliorate this well-documented phenomenon. In this systematic review, we have performed a comprehensive search of the literature to elucidate the studies that document a correlation between radiation-associated lymphopenia and survival outcomes in solid malignancies. We also summarize potential unifying paradigms that account for radiation-induced lymphopenia across studies and lay the groundwork for attempting to explain and/or counter this phenomenon.
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