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A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
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BRITISH JOURNAL OF PHARMACOLOGY (2006)
Isoprenylated proteins
SJ McTaggart
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
Inhibitors of Rho-kinase modulate amyloid-beta (A beta) secretion but lack selectivity for A beta 42
S Leuchtenberger et al.
JOURNAL OF NEUROCHEMISTRY (2006)
New players in TLR-mediated innate immunity - PI3K and small Rho GTPases
Monica Ruse et al.
IMMUNOLOGIC RESEARCH (2006)
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
OM Andersen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Evaluation of geranylazide and farnesylazide diphosphate for incorporation of prenylazides into a CAAX box-containing peptide using protein farnesyltransferase
MW Rose et al.
JOURNAL OF PEPTIDE RESEARCH (2005)
Statins cause intracellular accumulation of amyloid precursor protein, β-secretase-cleaved fragments, and amyloid β-peptide via an isoprenoid-dependent mechanism
SL Cole et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Opinion - Post-prenylation-processing enzymes as new targets in oncogenesis
AM Winter-Vann et al.
NATURE REVIEWS CANCER (2005)
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production
T Kukar et al.
NATURE MEDICINE (2005)
Postprenylation CAAX processing is required for proper localization of ras but not rho GTPases
D Michaelson et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
The Ras superfamily at a glance
K Wennerberg et al.
JOURNAL OF CELL SCIENCE (2005)
Purification, functional reconstitution, and characterization of the Saccharomyces cerevisiae isoprenylcysteine carboxylmethyltransferase Ste14p
JL Anderson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors attenuate β-amyloid-induced microglial inflammatory responses
A Cordle et al.
JOURNAL OF NEUROSCIENCE (2005)
Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK
S Pedrini et al.
PLOS MEDICINE (2005)
Profiling enzyme activities in vivo using click chemistry methods
AE Speers et al.
CHEMISTRY & BIOLOGY (2004)
Isoprenoids: Remarkable diversity of form and function
SA Holstein et al.
LIPIDS (2004)
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
J Choi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses
EM Blalock et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Loss of apolipoprotein E receptor LR11 in Alzheimer disease
CR Scherzer et al.
ARCHIVES OF NEUROLOGY (2004)
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity
TS Reid et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Structure of mammalian protein geranylgeranyltransferase type-I
JS Taylor et al.
EMBO JOURNAL (2003)
APP processing is regulated by cytoplasmic phosphorylation
MS Lee et al.
JOURNAL OF CELL BIOLOGY (2003)
Ras proteins: Different signals from different locations
JF Hancock
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase
TC Turek-Etienne et al.
BIOCHEMISTRY (2003)
Diazotrifluoropropionamido-containing prenylcysteines: Syntheses and applications for studying isoprenoid-protein interactions
TA Kale et al.
ORGANIC LETTERS (2003)
Protein farnesyl and N-myristoyl transferases:: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics
MH Gelb et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2003)
Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease
V Meske et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
Farnesyl protein transferase inhibitor ZARNESTRA (TM) R115777 - History of a discovery
M Venet et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2003)
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease:: A 26-week randomized, placebo-controlled, double-blind trial
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ANNALS OF NEUROLOGY (2002)
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part 1: Creatine kinase bb, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1
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FREE RADICAL BIOLOGY AND MEDICINE (2002)
Statin therapy for Alzheimer's disease - Will it work?
SS Petanceska et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2002)
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
RM Costa et al.
NATURE (2002)
Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages
FP Coxon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Decreased brain levels of 2′,3′-cyclic nucleotide-3′-phosphodiesterase in Down syndrome and Alzheimer's disease
R Vlkolinsky et al.
NEUROBIOLOGY OF AGING (2001)
Synthesis of farnesyl diphosphate analogues containing ether-linked photoactive benzophenones and their application in studies of protein prenyltransferases
TC Turek et al.
JOURNAL OF ORGANIC CHEMISTRY (2001)
A photoactivatable prenylated cysteine designed to study isoprenoid recognition
TA Kale et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Structural mechanism for statin inhibition of HMG-CoA reductase
ES Istvan et al.
SCIENCE (2001)
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
K Fassbender et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Isoprenylcysteine carboxyl methyltransferase deficiency in mice
MO Bergo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Toll-like receptor 2-mediated NF-κB activation requires a RacI-dependent pathway
L Arbibe et al.
NATURE IMMUNOLOGY (2000)
Human Ras-converting enzyme (hRCE1) endoproteolytic activity on K-Ras-derived peptides
I Hollander et al.
ANALYTICAL BIOCHEMISTRY (2000)
Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting
MD Ehlers
NEURON (2000)
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
B Wolozin et al.
ARCHIVES OF NEUROLOGY (2000)
The mammalian Rab family of small GTPases: Definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily
JB Pereira-Leal et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)
Protein geranylgeranylation is required for osteoclast formation, function, and survival: Inhibition by bisphosphonates and GGTI-298
FP Coxon et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2000)
Activation of oncogenic pathways in degenerating neurons in Alzheimer disease
XW Zhu et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2000)
Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells
MO Bergo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Studies with recombinant Saccharomyces cerevisiae CaaX prenyl protease Rcelp
JM Dolence et al.
BIOCHEMISTRY (2000)
Inflammation and Alzheimer's disease
H Akiyama et al.
NEUROBIOLOGY OF AGING (2000)
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
K Ohashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)