Related references
Note: Only part of the references are listed.Bile Acids and Nonalcoholic Fatty Liver Disease: Molecular Insights and Therapeutic Perspectives
Juan P. Arab et al.
HEPATOLOGY (2017)
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation
Jean-Charles Nault et al.
GASTROENTEROLOGY (2017)
Increased Risk of Mortality by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis
Parambir S. Dulai et al.
HEPATOLOGY (2017)
FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis
Sathish Kumar Natarajan et al.
JOURNAL OF LIPID RESEARCH (2017)
Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease
Candice Alexandra Grzelak et al.
PLOS ONE (2017)
Inhibition of Hedgehog Signaling Ameliorates Hepatic Inflammation in Mice With Nonalcoholic Fatty Liver Disease
Hyunjoo Kwon et al.
HEPATOLOGY (2016)
Hedgehog Signaling Activation in Hepatic Stellate Cells Promotes Angiogenesis and Vascular Mimicry in Hepatocellular Carcinoma
Wei Li et al.
CANCER INVESTIGATION (2016)
Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways
Jiao Liu et al.
CANCER LETTERS (2016)
Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis
Xiaobo Wang et al.
CELL METABOLISM (2016)
Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy
Ekaterina Pak et al.
DEVELOPMENTAL CELL (2016)
Pathogenesis of Nonalcoholic Steatohepatitis
Mariana Verdelho Machado et al.
GASTROENTEROLOGY (2016)
Global Epidemiology of Nonalcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes
Zobair M. Younossi et al.
HEPATOLOGY (2016)
Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium
Kasturi Pal et al.
JOURNAL OF CELL BIOLOGY (2016)
Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model
Sook In Chung et al.
JOURNAL OF HEPATOLOGY (2016)
Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
Ann Hanna et al.
MOLECULAR CANCER (2016)
A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma
Andrew H. Ko et al.
PANCREAS (2016)
Smoothened Regulation: A Tale of Two Signals
Angela M. Arensdorf et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma
Heng Cai et al.
TUMOR BIOLOGY (2016)
The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint
Laura Di Magno et al.
Oncotarget (2016)
Bridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells
P. Jakobs et al.
SCIENTIFIC REPORTS (2016)
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway
Audrey Fleury et al.
SCIENTIFIC REPORTS (2016)
Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis
Madlen Matz-Soja et al.
ELIFE (2016)
Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
Tadas K. Rimkus et al.
CANCERS (2016)
Sonic hedgehog signaling in hepatocellular carcinoma: A pilot study
Mohannad Dugum et al.
MOLECULAR AND CLINICAL ONCOLOGY (2016)
Regulation of Hedgehog Signalling Inside and Outside the Cell
Simon A. Ramsbottom et al.
JOURNAL OF DEVELOPMENTAL BIOLOGY (2016)
Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma
Kuo-Shyang Jeng et al.
AMERICAN JOURNAL OF SURGERY (2015)
Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling
Gisela D'Angelo et al.
DEVELOPMENTAL CELL (2015)
Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output
Marcelo Chavez et al.
DEVELOPMENTAL CELL (2015)
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling
Francesc R. Garcia-Gonzalo et al.
DEVELOPMENTAL CELL (2015)
Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States
Robert J. Wong et al.
GASTROENTEROLOGY (2015)
Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
Paul Angulo et al.
GASTROENTEROLOGY (2015)
Age-related differential gene and protein expression in postnatal cartilage canal and osteochondral junction chondrocytes
Katja Duesterdieck-Zellmer et al.
GENE EXPRESSION PATTERNS (2015)
Fibrosis Stage Is the Strongest Predictor for Disease-Specific Mortality in NAFLD After Up to 33 Years of Follow-Up
Mattias Ekstedt et al.
HEPATOLOGY (2015)
Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma
Chiao-Ling Tsai et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015)
Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease
Mariana Verdelho Machado et al.
JOURNAL OF HEPATOLOGY (2015)
Phase II evaluation of IPI-926, an oral Hedgehog inhibitor, in patients with myelofibrosis
Koji Sasaki et al.
LEUKEMIA & LYMPHOMA (2015)
Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion
Anup Parchure et al.
MOLECULAR BIOLOGY OF THE CELL (2015)
SIL1-related Marinesco-Sjoegren syndrome (MSS) with associated motor neuronopathy and bradykinetic movement disorder
Susan Byrne et al.
NEUROMUSCULAR DISORDERS (2015)
Differential Expression of Sonic Hedgehog Protein in Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
Redha Al-Bahrani et al.
PATHOLOGY & ONCOLOGY RESEARCH (2015)
Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1
Ljiljana Milenkovic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma
Yen-Hsing Li et al.
CELL REPORTS (2015)
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis
M. V. Machado et al.
GUT (2015)
Treatment Response in the PIVENS Trial Is Associated With Decreased Hedgehog Pathway Activity
Cynthia D. Guy et al.
HEPATOLOGY (2015)
Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease
Mariana Verdelho Machado et al.
PLOS ONE (2015)
An Overview of Hedgehog Signaling in Fibrosis
Liping Hu et al.
MOLECULAR PHARMACOLOGY (2015)
Alcohol Activates the Hedgehog Pathway and Induces Related Procarcinogenic Processes in the Alcohol-Preferring Rat Model of Hepatocarcinogenesis
Isaac S. Chan et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014)
Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis
Ali A. Mokdad et al.
BMC MEDICINE (2014)
Gli2 silencing enhances TRAIL-induced apoptosis and reduces tumor growth in human hepatoma cells in vivo
Da-wei Zhang et al.
CANCER BIOLOGY & THERAPY (2014)
Inhibition of Hedgehog signaling in the gastrointestinal tract: Targeting the cancer microenvironment
Juanita L. Merchant et al.
CANCER TREATMENT REVIEWS (2014)
Primary cilium: an elaborate structure that blocks cell division?
Yi-Ni Ke et al.
GENE (2014)
Saturated Free Fatty Acids Induce Cholangiocyte Lipoapoptosis
Sathish Kumar Natarajan et al.
HEPATOLOGY (2014)
Nonalcoholic Steatohepatitis Is the Most Rapidly Growing Indication for Liver Transplantation in Patients With Hepatocellular Carcinoma in the U. S.
Robert J. Wong et al.
HEPATOLOGY (2014)
Cyclopamine: From Cyclops Lambs to Cancer Treatment
Stephen T. Lee et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)
Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells
Petra Jakobs et al.
JOURNAL OF CELL SCIENCE (2014)
Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma
Nataliya Razumilava et al.
JOURNAL OF HEPATOLOGY (2014)
The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury
Candice Alexandra Grzelak et al.
JOURNAL OF HEPATOLOGY (2014)
Down-regulation of Gli-1 inhibits hepatocellular carcinoma cell migration and invasion
Jing-Song Chen et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2014)
The ESCRT machinery regulates the secretion and long-range activity of Hedgehog
Tamas Matusek et al.
NATURE (2014)
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment
Mu He et al.
NATURE CELL BIOLOGY (2014)
Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity
Marisa O. Peluso et al.
PLOS ONE (2014)
Canonical and non-canonical Hedgehog signalling and the control of metabolism
Raffaele Teperino et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)
Non-alcoholic fatty liver disease: What the clinician needs to know
Mariana Verdelho Machado et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2014)
Proliferative ductular reactions correlate with hepatic progenitor cell and predict recurrence in HCC patients after curative resection
Fei Ye et al.
CELL AND BIOSCIENCE (2014)
Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception
Shen Yue et al.
ELIFE (2014)
The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling
Saikat Mukhopadhyay et al.
CELL (2013)
Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
Antonio Jimeno et al.
CLINICAL CANCER RESEARCH (2013)
Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation
Guanhua Xie et al.
GUT (2013)
Hedgehog Pathway and Pediatric Nonalcoholic Fatty Liver Disease
Marzena Swiderska-Syn et al.
HEPATOLOGY (2013)
Hedgehog Signaling Pathway Regulates Autophagy in Human Hepatocellular Carcinoma Cells
Ying Wang et al.
HEPATOLOGY (2013)
Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition
Shamik Das et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Macrophage-derived hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni
Thiago A. Pereira et al.
LIVER INTERNATIONAL (2013)
GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
Scott X. Atwood et al.
NATURE (2013)
NAFLD, NASH and liver cancer
Gregory A. Michelotti et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2013)
The mechanisms of Hedgehog signalling and its roles in development and disease
James Briscoe et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Vismodegib Suppresses TRAIL-mediated Liver Injury in a Mouse Model of Nonalcoholic Steatohepatitis
Petra Hirsova et al.
PLOS ONE (2013)
Hedgehog inhibition reduces angiogenesis by downregulation of tumoral VEGF-A expression in hepatocellular carcinoma
Matthias Pinter et al.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2013)
The dawn of hedgehog inhibitors: Vismodegib
Selvarajan Sandhiya et al.
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS (2013)
Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway
Jing-tao Lu et al.
ACTA PHARMACOLOGICA SINICA (2012)
Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma
Isaac S. Chan et al.
CANCER RESEARCH (2012)
Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat
Raffaele Teperino et al.
CELL (2012)
Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients
Li Che et al.
CHINESE JOURNAL OF CANCER RESEARCH (2012)
A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia
Karolin V. Dorn et al.
DEVELOPMENTAL CELL (2012)
Cilia and Hedgehog: When and how was their marriage solemnized?
Sudipto Roy
DIFFERENTIATION (2012)
NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease
Wing-Kin Syn et al.
GUT (2012)
Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
Cynthia D. Guy et al.
HEPATOLOGY (2012)
A hedgehog survival pathway in 'undead' lipotoxic hepatocytes
Keisuke Kakisaka et al.
JOURNAL OF HEPATOLOGY (2012)
Hedgehog inhibitor gets landmark skin cancer approval, but questions remain for wider potential
Malini Guha
NATURE REVIEWS DRUG DISCOVERY (2012)
Blockade of the sonic hedgehog pathway effectively inhibits the growth of hepatoma in mice: An in vivo study
Kuo-Shyang Jeng et al.
ONCOLOGY LETTERS (2012)
Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand
Hanna Tukachinsky et al.
CELL REPORTS (2012)
Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
Giovanni Musso et al.
ANNALS OF MEDICINE (2011)
TGF-β Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling
Rachelle W. Johnson et al.
CANCER RESEARCH (2011)
Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation
Luisa Izzi et al.
DEVELOPMENTAL CELL (2011)
Osteopontin is Induced by Hedgehog Pathway Activation and Promotes Fibrosis Progression in Nonalcoholic Steatohepatitis
Wing-Kin Syn et al.
HEPATOLOGY (2011)
Hedgehog Activity, Epithelial-Mesenchymal Transitions, and Biliary Dysmorphogenesis in Biliary Atresia
Alessia Omenetti et al.
HEPATOLOGY (2011)
Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3β Regulates Its Stability and Localization in the Primary Cilium
Yan Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Heterotrimeric Gi Proteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration
Ariel H. Polizio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
Xin Chen et al.
JOURNAL OF CELL BIOLOGY (2011)
Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations
Xiaoli Chen et al.
JOURNAL OF HEPATOLOGY (2011)
Increased production of sonic hedgehog by ballooned hepatocytes
Fatima Rangwala et al.
JOURNAL OF PATHOLOGY (2011)
Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity
Yannis E. Mavromatakis et al.
MECHANISMS OF DEVELOPMENT (2011)
Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer
George M. Philips et al.
PLOS ONE (2011)
Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
Yesser H. Belgacem et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice
Tonny W. Naranjo et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2011)
Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened
Yongbin Chen et al.
PLOS BIOLOGY (2011)
Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
James Kim et al.
CANCER CELL (2010)
Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
Pilar Chinchilla et al.
CELL CYCLE (2010)
The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance
Karisa C. Schreck et al.
CLINICAL CANCER RESEARCH (2010)
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
Chengbing Wang et al.
DEVELOPMENT (2010)
Signals from dying hepatocytes trigger growth of liver progenitors
Youngmi Jung et al.
GUT (2010)
Accumulation of Natural Killer T Cells in Progressive Nonalcoholic Fatty Liver Disease
Wing-Kin Syn et al.
HEPATOLOGY (2010)
Hedgehog Signaling Is Critical for Normal Liver Regeneration After Partial Hepatectomy in Mice
Begona Ochoa et al.
HEPATOLOGY (2010)
Histopathologic and immunologic effects of the itraconazole treatment in a murine model of chronic pulmonary paracoccidioidomycosis
Tonny W. Naranjo et al.
MICROBES AND INFECTION (2010)
Inhibition of Endogenous Hedgehog Signaling Protects Against Acute Liver Injury After Ischemia Reperfusion
Akshay Pratap et al.
PHARMACEUTICAL RESEARCH (2010)
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis
Steve S. Choi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)
A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
Barbara Stecca et al.
EMBO JOURNAL (2009)
Role for hedgehog pathway in regulating growth and function of invariant NKT cells
Wing-Kin Syn et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2009)
Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease
Wing-Kin Syn et al.
GASTROENTEROLOGY (2009)
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
Olivier Nolan-Stevaux et al.
GENES & DEVELOPMENT (2009)
Repair-Related Activation of Hedgehog Signaling Promotes Cholangiocyte Chemokine Production
Alessia Omenetti et al.
HEPATOLOGY (2009)
Protein Kinase Cδ Negatively Regulates Hedgehog Signaling by Inhibition of Gli1 Activity
Qingsong Cai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A small molecule that binds Hedgehog and blocks its signaling in human cells
Benjamin Z. Stanton et al.
NATURE CHEMICAL BIOLOGY (2009)
Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
Rajat Rohatgi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The hedgehog pathway regulates remodelling responses to biliary obstruction in rats
A. Omenetti et al.
GUT (2008)
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
Liu Yang et al.
JOURNAL OF HEPATOLOGY (2008)
β-arrestin-mediated localization of smoothened to the primary cilium
Jeffrey J. Kovacs et al.
SCIENCE (2008)
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
Maarten F. Bijlsma et al.
CELLULAR SIGNALLING (2007)
Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice
Susanne V. Fleig et al.
LABORATORY INVESTIGATION (2007)
Patched1 regulates Hedgehog signaling at the primary cilium
Rajat Rohatgi et al.
SCIENCE (2007)
Induction of sonic hedgehog mediators by transforming growth factor-β:: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
Sylviane Dennler et al.
CANCER RESEARCH (2007)
Progressive fibrosis in nonalcoholic steato hepatitis: Association with altered regeneration and a ductular reaction
Michelle M. Richardson et al.
GASTROENTEROLOGY (2007)
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
Matthias Lauth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis
Youngmi Jung et al.
HEPATOLOGY (2007)
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
Yong Pan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Melanomas require HEDGEHOG-GLI signaling reaulated by interactions between GLI1 and the RAS-MEK/AKT pathways
Barbara Stecca et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Repression of smoothened by patched-dependent (Pro-)Vitamin D3 secretion
Maarten F. Bijlsma et al.
PLOS BIOLOGY (2006)
Hedgehog signaling maintains resident hepatic progenitors throughout life
JK Sicklick et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis
JK Sicklick et al.
CARCINOGENESIS (2006)
A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form
JA Goetz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Evidence for the direct involvement of βTrCP in Gli3 protein processing
BW Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Role for Hedgehog signaling in hepatic stellate cell activation and viability
JK Sicklick et al.
LABORATORY INVESTIGATION (2005)
Vertebrate Smoothened functions at the primary cilium
KC Corbit et al.
NATURE (2005)
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
AM Liu et al.
DEVELOPMENT (2005)
Lipoprotein particles are required for Hedgehog and Wingless signalling
D Panáková et al.
NATURE (2005)
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
MH Chen et al.
GENES & DEVELOPMENT (2004)
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter
MS Ikram et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2004)
Patched acts catalytically to suppress the activity of Smoothened
J Taipale et al.
NATURE (2002)
Patched1 interacts with cyclin B1 to regulate cell cycle progression
EA Barnes et al.
EMBO JOURNAL (2001)
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
J Taipale et al.
NATURE (2000)
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
N Denef et al.
CELL (2000)