Journal
CRITICAL CARE CLINICS
Volume 34, Issue 1, Pages 63-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccc.2017.08.003
Keywords
Sepsis; Organ dysfunction; Microcirculation; Mitochondria; Metabolism; Inflammation
Categories
Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [K08GM117310] Funding Source: NIH RePORTER
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Sepsis-associated organ dysfunction involves multiple responses to inflammation, including endothelial and microvascular dysfunction, immune and autonomic dysregulation, and cellular metabolic reprogramming. The effect of targeting these mechanistic pathways on short- and long-term outcomes depends highly on the timing of therapeutic intervention. Furthermore, there is a need to understand the adaptive or maladaptive character of these mechanisms, to discover phase-specific biomarkers to guide therapy, and to conceptualize these mechanisms in terms of resistance and tolerance.
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