Journal
NATURE REVIEWS CANCER
Volume 15, Issue 11, Pages 639-652Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3995
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Funding
- Swiss Cancer League [KLS 3388-02-2014]
- European Research Council [AdG 340227]
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Over a century ago, centrosome aberrations were postulated to cause cancer by promoting genome instability. The mechanisms governing centrosome assembly and function are increasingly well understood, allowing for a timely reappraisal of this postulate. This Review discusses recent advances that shed new light on the relationship between centrosomes and cancer, and raise the possibility that centrosome aberrations contribute to this disease in different ways than initially envisaged.
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