Journal
SLEEP SCIENCE
Volume 8, Issue 3, Pages 143-152Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.slsci.2015.09.002
Keywords
Sleep; Stress; Metabolism; Cortisol; Hypothalamicpituitaryadrenal axis; Obesity
Categories
Funding
- Associacao Fundo de Incentivo a Pesquisa (AFIP) from Sao Paulo Research Foundation (FAPESP) [14/15259-2]
- CNPq [305177/2013-3, 301974/2011-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [14/15259-2] Funding Source: FAPESP
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Poor sleep quality due to sleep disorders and sleep loss is highly prevalent in the modern society. Underlying mechanisms show that stress is involved in the relationship between sleep and metabolism through hypothalamicpituitaryadrenal (HPA) axis activation. Sleep deprivation and sleep disorders are associated with maladaptive changes in the HPA axis, leading to neuroendocrine dysregulation. Excess of glucocorticoids increase glucose and insulin and decrease adiponectin levels. Thus, this review provides overall view of the relationship between sleep, stress, and metabolism from basic physiology to pathological conditions, highlighting effective treatments for metabolic disturbances. (C) 2015 Brazilian Associationof Sleep. Production and Hosting by Elsevier B.V.
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