Journal
FOOD SCIENCE AND BIOTECHNOLOGY
Volume 24, Issue 2, Pages 699-704Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
DOI: 10.1007/s10068-015-0091-2
Keywords
fucoidan; osteoblast; migration; bone regeneration; cytoskeleton
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Funding
- Fishery Commercialization Technology Development Program, Ministry for Agriculture, Food and Rural Affairs, Korea
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science, and Technology [2011-0022220]
- National Research Foundation of Korea [2011-0022220] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Fucoidan has been reported to induce the differentiation and mineralization of osteoblastic cells. Here we investigated the effects of fucoidan on the morphology and migration of osteoblasts and found that the effects of fucoidan on the migration of osteoblasts vary depending on the conditions under which the cells are treated. A migration assay using cells treated with fucoidan before stable attachment on plates showed slightly increased migration of fucoidan-treated cells compared to control cells, whereas wound healing experiments using stably attached cells exhibited a slightly decreased migration. The fucoidan-treated cells became shrunk and rounded and showed significantly decreased spreading and adhesion compared to control cells. F-actin was highly accumulated at the rounded cell cortex by fucoidan treatment. These studies suggest that the slightly increased migration of cells in the presence of fucoidan might be correlated to the morphological changes and decreased adhesion.
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