Journal
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Volume 15, Issue 2, Pages 148-156Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15412555.2018.1432034
Keywords
Angiotensin converting enzyme inhibitor; angiotensin receptor blocker; chronic obstructive pulmonary disease; renin-angiotensin system
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Chronic obstructive pulmonary disease (COPD) is a complex disorder that primarily affects the lungs and is characterized not only by local pulmonary, but also by systemic inflammation which promotes the development of extrapulmonary and cardiovascular co-morbidities. Angiotensin converting enzyme (ACE) inhibitors and ARBs (angiotensin receptor blockers) are widely used drugs in the treatment of cardiovascular diseases, with growing evidence suggesting potential benefits in COPD patients. The purpose of this review is to describe the correlation of renin-angiotensin system(RAS) with COPD pathophysiology and to present the latest data regarding the potential role of RAS blockers in COPD.
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