Journal
COORDINATION CHEMISTRY REVIEWS
Volume 374, Issue -, Pages 36-54Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2018.06.013
Keywords
Fluorescence probes; Peroxynitrite; Boronic acids or boronates; N-dearylation; Intracellular imaging; In vivo imaging; Reactive oxygen species (ROS)
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Funding
- National Natural Science Foundation of China [31371750]
- Hubei Provincial Natural Science Foundation [2018CFB264]
- National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) - Korean government (MSIP) [2012R1A3A2048814, 2018R1A3B1052702]
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Peroxynitrite (ONOO-) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO-, with high biocompatibilities, sensitivities, and site specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO- and their biological applications in diverse living systems. (C) 2018 Elsevier B.V. All rights reserved
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