Journal
COORDINATION CHEMISTRY REVIEWS
Volume 364, Issue -, Pages 118-136Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2018.03.008
Keywords
Silver nanoparticles; Sulfur; Chloride; Silver speciation; Electron microscopy; Cellular imaging
Categories
Funding
- CEA-Toxicology Transversal Program through the NanoSilverSol grant
- CEA Transversal Programs Toxicology and Nanoscience through the NanoTox-RX grant
- LabEx SERENADE [ANR-11-LABX-0064]
- LabEx ARCANE [ANR-11-LABX-0003-01]
- CEA DRF-Impulsion grant FIB-Bio
- Universite Grenoble Alpes - AGIR grant NanoSilverSafe
- FRISBI, within the Grenoble Partnership for Structural Biology (PSB) [ANR-10-INSB-05-02]
- GRAL, within the Grenoble Partnership for Structural Biology (PSB) [ANR-10-LABX-49-01]
- Rhone-Alpes Region
- Fondation Recherche Medicale (FRM)
- fonds FEDER
- Centre National de la Recherche Scientifique (CNRS)
- CEA
- University of Grenoble
- EMBL
- GIS-Infrastrutures en Biologie Sante et Agronomie (IBISA)
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Silver nanoparticles (AgNPs) are exponentially used in various consumer products including medical devices. This production leads to an increasing human exposure to silver in different forms. Indeed, AgNPs are subject to various transformations in aqueous aerobic conditions that trigger the production of Ag(I) species. The main environmental transformation produces the non-toxic species silver sulfide. Transformations occurring in mammals are more diverse and mainly depend on the interaction of AgNPs with thiol, chloride and proteins. Any of these species have a different impact on AgNPs and induces AgNP dissolution into Ag(I) species, aggregation and/or stabilization. The transformations occurring also depend on the exposure route. The main one is dietary but medical exposure is also growing with the massive use of nanosilver as biocide in medical devices. For the former, AgNP modifications and Ag distribution has been extensively studied using in vitro and in vivo models, while data related to medical use of nanosilver are scarce. However, most of the in vitro and in vivo data often remain inconsistent. In this review, we describe both in vitro, in cellulo and in vivo data about AgNP transformations, silver speciation and biodistribution. We try to reconcile all these data and describe the latest methods for the future studies of AgNP fate in mammals. (C) 2018 Elsevier B.V. An rights reserved.
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