Journal
FOOD SCIENCE AND BIOTECHNOLOGY
Volume 24, Issue 1, Pages 347-351Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
DOI: 10.1007/s10068-015-0046-7
Keywords
breast cancer; invasion; matrix metalloproteinase; migration; sulforaphane
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Funding
- Cooperative Research Program for Agriculture Science and Technology Development [PJ008550]
- Rural Development Administration
- Bio-Synergy Research Project of the Ministry of Science, ICT and Future Planning through the National Research Foundation [NRF-2013M3A9C4078156]
- Chung-Ang University Excellent Student Scholarship
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Sulforaphane significantly (p < 0.05) inhibited tumor necrosis factor (TNF)-alpha induced cellular migration and invasion in MCF10DCIS.com human breast cancer cells, compared with controls. mRNA and protein expressions of MMPs, including MMP-2, MMP-9, and MMP-13, and the enzymatic activities of MMP-2 and MMP-9 were suppressed by sulforaphane treatments at 1, 5, and 10 mu M concentration in MCF10DCIS.com cells. Sulforaphane should be considered as a potent agent for retardation of mammary tumorigenesis.
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