Journal
CONTRAST MEDIA & MOLECULAR IMAGING
Volume -, Issue -, Pages -Publisher
WILEY-HINDAWI
DOI: 10.1155/2018/2198703
Keywords
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Funding
- Associazione Italiana per la Ricerca sul Cancro [11993]
- Italian Ministry of Education, University and Research (MIUR) through the project FIRB Riname [RBAP114AMK]
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Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacteria: magnetosomes. The efficacy of such protocol is tested in a xenograft model of glioblastoma. Mice receive a single intratumoral injection of magnetosomes, and they are exposed three tones in a week to an alternating magnetic field with concurrent temperature measurements. MRI is used to visualise the nanoparticles and to monitor tumor size before and after the treatment. Statistically significant inhibition of the tumor growth is detected in subjects exposed to the alternating magnetic field compared to control groups. Moreover, thanks to magnetosomes high transversal relaxivity, their effective delivery to the tumor tissue is monitored by M RI. It is apparent that the efficacy of this protocol is limited by inhomogeneous delivery of magnetosomes to tumor tissue. These results suggest that naturally synthesized magnetosomes could be effectively considered as theranostic agent candidates for hyperthermia based on iron oxide nanoparticles.
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