Journal
NATURE REVIEWS IMMUNOLOGY
Volume 15, Issue 11, Pages 683-691Publisher
NATURE PORTFOLIO
DOI: 10.1038/nri3904
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Funding
- European Research Council [StG_260352]
- Investigator FCT
- Fundacao para a Ciencia e Tecnologia
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With the promise of T cell-based therapy for cancer finally becoming reality, this Review focuses on the less-studied gamma delta T cell lineage and its diverse responses to tumours gamma delta T cells have well-established protective roles in cancer, largely on the basis of their potent cytotoxicity and interferon-gamma production. Besides this, recent studies have revealed a series of tumour-promoting functions that are linked to interleukin-17-producing gamma delta T cells. Here, we integrate the current knowledge from both human and mouse studies to highlight the potential of gamma delta T cell modulation to improve cancer immunotherapy.
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