Journal
ACTA RADIOLOGICA OPEN
Volume 4, Issue 11, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/2058460115609635
Keywords
Magnetic resonance imaging (MRI); intrathecal; contrast medium; brain; paravascular transport; glymphatic circulation
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Recently, the glymphatic system of the brain has been discovered in rodents, which is a paravascular, transparenchymal route for clearance of excess brain metabolites and distribution of compounds in the cerebrospinal fluid. It has already been demonstrated that intrathecally administered gadolinium (Gd) contrast medium distributes along this route in rats, but so far not in humans. A 27-year-old woman underwent magnetic resonance imaging (MRI) with intrathecal administration of gadobutrol, which distributed throughout her entire brain after 1 and 4.5 h. MRI with intrathecal Gd may become a tool to study glymphatic function in the human brain.
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