Journal
EMERGING INFECTIOUS DISEASES
Volume 21, Issue 11, Pages 2014-2021Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2111.150548
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Funding
- National Institutes of Health (National Institute of Allergy and Infectious Diseases) [5K08AI112506-02]
- Children's Foundation
- Global Antibiotic Resistance Partnership
- Bill and Melinda Gates Foundation
- Health Grand Challenges Program at Princeton University
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The prevalence of carbapenem-resistant Enterobacteriaceae (ORE) infections is increasing in the United States. However, few studies have addressed their epidemiology in children. To phenotypically identify CRE isolates cultured from patients 1-17 years of age, we used antimicrobial susceptibilities of Enterobacteriaceae reported to 300 laboratories participating in The Surveillance Network USA database during January 1999-July 2012. Of 316,253 isolates analyzed, 266 (0.08%) were identified as ORE. ORE infection rate increases were highest for Enterobacter species, blood culture isolates, and isolates from intensive care units, increasing from 0.0% in 1999-2000 to 5.2%, 4.5%, and 3.2%, respectively, in 2011-2012. ORE occurrence in children is increasing but remains low and is less common than that for extended-spectrum beta-lactamase producing Enterobacteriaceae. The molecular characterization of ORE isolates from children and clinical epidemiology of infection are essential for development of effective prevention strategies.
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