Journal
COMPOSITES PART B-ENGINEERING
Volume 143, Issue -, Pages 243-249Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.compositesb.2018.02.009
Keywords
Fluoride calcium silicate; Apatite; Biological properties; Biocompatibility
Funding
- Key Project of Sichuan Science and Technology Department [2017GZ0402, 2016GZ0196]
- National Key Research and Development Program of China [2016YFC1102000]
- 111 Project of China [B16033]
- Sichuan Province Major Scientific & Technological Achievements Transformation Demonstration Project [2016CZYD0004]
- Sichuan Province Science & Technology Department key projects [2017SZ0001]
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Fluoride calcium silicate (FCS) are widely used in dental tissue engineering due to their excellent biological properties. This study aimed to develop novel FCS with multiple biofunctions as toothpaste additives. In this study, the preparation of composite FCS, morphologies of the composites and the in vitro biofunctions were investigated. Calcium silicate with 0.7% (wt) fluoride was prepared by co-precipitation method. Pure calcium silicate (CS) was synthesized for controlling study. Biomimetic mineralization study was conducted in simulated body fluid (SBF), the composition, phase structure, apatite formation and morphology were investigated by Xray Fluorescence Analysis (XPS), X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and transmission electron microscope (TEM). In vitro cell viability studies showed that the fluoride ions promoted cell proliferation and differentiation. This study indicated that FCS shown good bioactivity to induce apatite formation and it could be a promising toothpaste additives with specific biofunction.
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