Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 43, Issue 12, Pages 3025-3039Publisher
SPRINGER
DOI: 10.1007/s10439-015-1343-2
Keywords
Microfluidics; Hydrogel; Collagen; Fibrin; Chemotaxis; Mechanical properties
Categories
Funding
- European Research Council (ERC) [ERC-2012-StG 306751]
- Spanish Ministry of Economy and Competitiveness [DPI2012-38090-C03-01]
- MINECO [SAF2011-24953]
- Fundacion Areces
- Ramon y Cajal Program
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Cell migration in 3D is a key process in many physiological and pathological processes. Although valuable knowledge has been accumulated through analysis of various 2D models, some of these insights are not directly applicable to migration in 3D. In this study, we have confined biomimetic hydrogels within microfluidic platforms in the presence of a chemoattractant (platelet-derived growth factor-BB). We have characterized the migratory responses of human fibroblasts within them, particularly focusing on the role of non-muscle myosin II. Our results indicate a prominent role for myosin II in the integration of chemotactic and haptotactic migratory responses of fibroblasts in 3D confined environments.
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