Journal
JOURNAL OF BEHAVIORAL MEDICINE
Volume 38, Issue 6, Pages 922-931Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10865-015-9658-x
Keywords
Interpersonal conflict at work; Negative affectivity; Work-related stress; Interleukin 1 beta; Interleukin 12; Interleukin 17
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This study examined the association between interpersonal conflict at work (ICW) and serum levels of three possible biomarkers of stress, namely the pro-inflammatory cytokines Interleukin 1 beta (IL-1 beta), Interleukin 12 (IL-12), and Interleukin 17 (IL-17). Additionally, this study investigated the role of negative affectivity (NA) in the relationship between ICW and the pro-inflammatory cytokines. Data from 121 employees in an Italian healthcare organization were analyzed using structural equation modeling. Results showed that ICW was positively associated with IL-1 beta, IL-12, and IL-17, after controlling for the effect of gender. Moreover, ICW completely mediated the relationship between NA and the pro-inflammatory cytokines IL-1 beta, IL-12, and IL-17. This mediating effect was significant after controlling for the effect of gender. Overall, this study suggests that work-related stress may be associated with biomarkers of inflammation, and that negative affectivity may influence the stress process affecting the exposure to psychosocial stressors.
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