Journal
FOOD HYDROCOLLOIDS
Volume 51, Issue -, Pages 476-485Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2015.05.036
Keywords
Oxidized konjac glucomannan (OKGM); Chitosan oligosaccharides (COS); Anthocyanins encapsulation; Intestine targeted delivery; In vitro release
Categories
Funding
- National Natural Science Foundation of China (NSFC) [31201334, 31471577]
- Fundamental Research Funds for the Central Universities [ZZ1404, ZY1329, YS1407]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [LXJJ201304]
Ask authors/readers for more resources
A novel oxidized konjac glucomannan (OKGM) microsphere system was developed to protect and targeted deliver the sensitive antioxidant-anthocyanins into intestine. The microspheres were made of oxidized konjac glucomannan, which was cross-linked by Fe3+ via emulsification method. The absorption of anthocyanins was driven by the electrostatic interaction between the negatively charged OKGM microspheres and positively charged anthocyanins. CLSM images showed that anthocyanins distributed homogenously through the OKGM microspheres. The absorption and release behavior of anthocyanins on OKGM microspheres were determined as a function of pH and salt concentration. A maximum absorption capacity was obtained at pH 3 and low salt concentration. However, anthocyanins were released significantly at simulated stomach conditions due to fast degradation of OKGM microspheres. An extra positively charged chitosan oligosaccharides (COS) layer was applied on OKGM microspheres to prevent H+ ions permeating into microspheres under stomach condition. COS oligomers were cross-linked with glutaraldehyde to further strengthen the OKGM microspheres' structure. Finally, glutaraldehyde cross-linked COS stabilized OKGM microspheres became stable against H+ ions in simulated stomach condition, therefore OKGM microspheres can prevent an early release of the anthocyanins in stomach condition and achieve a sustained released in the intestinal condition. The in vitro release experiments revealed that the OKGM microspheres had a potential as a carrier of targeted delivery of bioactive compounds in the intestine. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available