Journal
REGENERATIVE BIOMATERIALS
Volume 2, Issue 4, Pages 273-280Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rb/rbv024
Keywords
gold nanostructures; cellular internalization; size, shape; surface chemistry
Categories
Funding
- Chinese Natural Science Foundation [81171455]
- key project [31430031]
- National Natural Science Foundation of China [31225009]
- State High-Tech Development Plan [2012AA020804, SS2014AA020708]
- BIC
- Chinese Academy of Science [121D11KYSB20130006, XDA09030301]
- Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province [14961302D]
- Hebei Province 'Hundred Talents Program' [BR2202]
- Hebei Province 'Three Three Three Talents Program' [A201401002]
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Unique physicochemical properties of Au nanomaterials make them potential star materials in biomedical applications. However, we still know a little about the basic problem of what really matters in fabrication of Au nanomaterials which can get into biological systems, especially cells, with high efficiency. An understanding of how the physicochemical properties of Au nanomaterials affect their cell internalization is of significant interest. Studies devoted to clarify the functions of various properties of Au nanostructures such as size, shape and kinds of surface characteristics in cell internalization are under way. These fundamental investigations will give us a foundation for constructing Au nanomaterial- based biomedical devices in the future. In this review, we present the current advances and rationales in study of the relationship between the physicochemical properties of Au nanomaterials and cell uptake. We also provide a perspective on the Au nanomaterial- cell interaction research.
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