Journal
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
Volume 1, Issue 4, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/2057-1976/1/4/045209
Keywords
radiotherapy; oxygen; oxygen effect; radiation damage
Funding
- Cancer Research UK [C5255/A15935, C53469/A19834]
- Cancer Research UK [19834] Funding Source: researchfish
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The presence of oxygen in tumours has substantial impact on treatment outcome; relative to anoxic regions, well-oxygenated cells respond better to radiotherapy by a factor 2.5-3. This increased radio-response is known as the oxygen enhancement ratio. The oxygen effect is most commonly explained by the oxygen fixation hypothesis, which postulates that radical-induced DNA damage can be permanently 'fixed' by molecular oxygen, rendering DNA damage irreparable. While this oxygen effect is important in both existing therapy and for future modalities such a radiation dose-painting, the majority of existing mathematical models for oxygen enhancement are empirical rather than based on the underlying physics and radiochemistry. Here we propose a model of oxygen-enhanced damage from physical first principles, investigating factors that might influence the cell kill. This is fitted to a range of experimental oxygen curves from literature and shown to describe them well, yielding a single robust term for oxygen interaction obtained. The model also reveals a small thermal dependency exists but that this is unlikely to be exploitable.
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