Journal
REGENERATIVE BIOMATERIALS
Volume 2, Issue 4, Pages 267-272Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rb/rbv018
Keywords
biomaterial-cell interaction; regenerative mechanism; stem cells
Categories
Funding
- European Commission
- German Research Foundation (DFG) [SPP1313]
- German Federal Ministry of Education & Research (BMBF) [0315033]
- German Federal Ministry of Defense (BMVg) [E/UR3G/4G392/4A804, FV M/SAB1/7A011, M/SABX/AA007]
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By definition, biomaterials are developed for clinical application. In the field of regenerative medicine their principal function is to play a significant, and, if possible, an instructive role in tissue healing. In the last analysis the latter involves targeting the 'regenerative niche'. The present paper will address the problem of simulating this niche in the laboratory and adopts a life science approach involving the harnessing of heterotypic cellular communication to achieve this, that is, the ability of cells of different types to mutually influence cellular functions. Thus, co-culture systems using human cells are the methodological focus and will concern four exemplary fields of regeneration, namely, bone, soft tissue, lower respiratory tract and airway regeneration. The working hypothesis underlying this approach is that in vitro models of higher complexity will be more clinically relevant than simple monolayer cultures of transformed cell lines in testing innovative strategies with biomaterials for regeneration.
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