Journal
PATHOGENS
Volume 4, Issue 4, Pages 793-815Publisher
MDPI
DOI: 10.3390/pathogens4040793
Keywords
Staphylococcus aureus; immunomodulation; disease tolerance; microbiome; interleukin-10
Categories
Funding
- Canadian Institutes of Health Research (CIHR)
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The Gram-positive bacterium Staphylococcus aureus is one of the most frequent pathogens that causes severe morbidity and mortality throughout the world. S. aureus can infect skin and soft tissues or become invasive leading to diseases such as pneumonia, endocarditis, sepsis or toxic shock syndrome. In contrast, S. aureus is also a common commensal microbe and is often part of the human nasal microbiome without causing any apparent disease. In this review, we explore the immunomodulation and disease tolerance mechanisms that promote commensalism to S. aureus.
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